![]() Melatonin is particularly beneficial to help to overcome jetlag (especially when travelling eastbound over more that 2 time zones) and for shift workers with altered sleep schedules. Generally, melatonin is used for difficulty falling asleep, waking in the night, and improving overall sleep quality. Hoevenaar-Blom MP, Spijkerman AM, Kromhout D, van den Berg JF, Verschuren WM (2011) Sleep duration and sleep quality in relation to 12-year cardiovascular disease incidence: the MORGEN study.Melatonin is best known for its effectiveness as a sleep aid and regulating the sleep-wake cycle. Diabetes Care 33(2):414–420Ĭappuccio FP, Taggart FM, Kandala NB, Currie A, Peile E, Stranges S et al (2008) Meta-analysis of short sleep duration and obesity in children and adults. 81(3):521–38Ĭappuccio FP, D’Elia L, Strazzullo P, Miller MA (2010) Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Anais da Academia Brasileira de Ciencias. ![]() Tufik S, Andersen ML, Bittencourt LR, Mello MT (2009) Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Rev Med Chir Soc Med Nat Iasi 116(3):862–866 Springer-Verlag GmbH, DE part of Springer Nature.Īmihaesei IC, Mungiu OC (2012) Main neuroendocrine features and therapy in primary sleep troubles. Melatonin Meta-analysis PSQI Sleep quality. In adults with respiratory diseases, metabolic disorders, primary sleep disorders, not with mental disorders, neurodegenerative diseases and other diseases. We found that the treatment with exogenous melatonin has positive effects on sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) in adult. Subgroup analysis based on health status revealed melatonin intervention in subjects with Respiratory diseases (WMD: - 2.20 95% CI - 2.97, - 1.44, p = 0.000), Metabolic disorders (WMD: - 2.74 95% CI - 3.48, - 2.00, p = 0.000) and sleep disorders (WMD: - 0.67 95% CI - 0.98, - 0.37, p = 0.000) has significant effect on sleep quality. Subgroup analysis based on health status and kind of intervention were potential between-study heterogeneity. There was significant heterogeneity between studies (I 2 = 80.7%, p = 0.000). Our results indicated that melatonin had significant effect on sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) (WMD: - 1.24 95% CI - 1.77, - 0.71, p = 0.000). ![]() Of 2642 papers, 23 RCTs met inclusion criteria. To determine the predefined sources of heterogeneity, subgroup analysis was performed. Heterogeneity among studies was evaluated by the Cochrane Q test and I-squared (I2). Results were summarized as mean differences (MD) with 95% confidence intervals (CI) using random effects model (DerSimonian-Laird method). The literature searches of English publications in MEDLINE and EMBASE databases were performed up June 2020. We summarized evidence from randomized clinical trials (RCTs) that investigated the effects of melatonin on sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) in adults with various diseases. The Present study was conducted to systematically review the effect of the melatonin on sleep quality.
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